My theory

These books are written as part of a one big theory which states that disease pathogenesis is the same regardless of the cause, age, or affected organ, and that membrane microdomain disorganization is related, directly or indirectly, to the pathogenesis of all diseases. The mechanism of any disease can be explained by knowing the nature of the resulting membrane microdomain phenotype. The basic principles governing membrane microdomain disorganization disorders are applied similarly to humans, animals, and plants.

Membrane microdomain phenotypes are measured by modulations that affect the membrane throughout the life of affected organism. There are two main pathogenic membrane microdomain phenotypes; raft building and raft-dependent activities are “impaired” in one and “increased” in the other. The clinical phenotype of both pathogenic membrane microdomain phenotypes is triggered or augmented by various factors, defined herein as a “raft disrupting mediators”. “Passive raft disruption”, augmented by “raft disrupting mediators”, is increased in both pathogenic membrane phenotypes. However, raft re-building is “impaired” in the non-inflammatory disorders and “increased” in the chronic inflammatory disorders (e.g. autoimmune diseases and cancer).

Treatment modalities can be created by re-organizing membrane microdomain phenotypes. For example, chronic inflammatory membrane microdomain phenotypes can be treated by aborting raft building; which can be achieved by accelerating, or paradoxically, by inhibiting “passive raft disruption”.