Before you start

Dear colleagues,

I have been working in the last 14 years on my own theory about the disease mechanism.
Within this time frame, I wrote more than 11500 pages included within 83 books, all were about disease mechanism and therapeutic options based on modulations of membrane microdomain phenotypes (membrane lipid rafts), in a new and previously undiscovered way. Before reading any book, please read these instructions which will lay the groundwork and help in understanding the basic concepts included within the book series.

The basic components of my theory include the following;

  1. The disease mechanism is the same regardless of the affected organ, cause, or age of affected person.

  2. Membrane microdomain disorganization is related, directly or indirectly, to the pathogenesis of all disorders, regardless of the age, affected organ, or cause.
  3. The disease mechanism, with regard to membrane microdomain phenotypes, is the same in humans, animals, and plants.
  4. Most, if not all, drugs function by modulating membrane microdomain phenotypes.
  5. There are two main basic pathogenic membrane microdomain phenotypes; one with impaired raft building and raft-dependent activities and the other with uncontrolled raft building and raft-dependent activities.
  6. Any disease (literally any disease) is caused by one of the above mentioned two pathogenic membrane microdomain phenotypes.
  7. Treatment of uncontrolled raft-dependent diseases can be achieved by converting into the second pathogenic membrane microdomain phenotype; i.e. by converting too much raft building membrane microdomain phenotype into too little raft building membrane microdomain phenotype.

My primary aim was to write one large book about the disease mechanism in all organs, all diseases, and at any age. However, it became so large that I had to include all written knowledge in more than 83 books.
These books are not about pediatric gastroenterology or hepatology, but they include everything in medicine including basic physiology (based on membrane microdomain organization) of exocytosis, apoptosis, cytokinesis, shedding of microvesicles, unconventional secretion, primary cilia, chloride secretion, chronic inflammation, proliferation, and cancer. It also includes the mechanism and disease pathogenesis (also based on abnormal membrane microdomain organization) of diseases in the liver, gut, pancreas, eyes, kidneys, blood, and brain. Diseases included within these books range from diseases of prematurity to diseases of old age including Alzheimer’s disease and aging.

Some important notes about these books are worth mentioning herein;

  1. The contents of these books are not written as part of updates or reviews about certain subjects in medicine. The contents in more than 80 books are related to one main subject about basic physiology, disease mechanism, and therapeutic options related to membrane microdomain organization/disorganization in such a way that have never been explored before.
  2. Each book contains three chapters. The first two chapters and the first few sections in the third chapter are repeated in most of the books. The reasons for repeating these chapters in each book are; (i) I assumed that colleagues will be selective and may read only few books according to their interest. The book contents are difficult to understand without reading the basic concept of the theory which is included in the first two chapters. (ii) As part of re-enforcement about the basic theory and its implications. (iii) The contents in each book and its related subject can not be understood without mentioning the basic concept of the theory which is included in the first two chapters. Regardless of the repetitions, each book contains detailed discussion related to the main specific subject that is not available in other books.
  3. The reader should be aware that understanding the contents will not be an easy task. In order to understand the contents, the reader should have some knowledge about membrane lipid rafts, exocytosis, shedding of microvesicles, unconventional secretion, and primary ciliopathies. I wrote separate books for each of these concepts, based on their relation to membrane microdomain organization.
  4. The reader should initially understand certain terms that I introduced and are not reported before in the literature. Some of these terms include;
    “Active raft building”
    “Active raft disruption”
    “Passive raft disruption”
    “Raft disrupting mediators”
    “Persistent and uncontrolled passive raft disruption with impaired re-building”
    “Persistent and uncontrolled raft building with impaired disruption”
    “Persistent and uncontrolled cycling of raft building and disruption”
    “Persistent and uncontrolled cycling of raft disruption and re-building”
    “Massive raft disruption that occurs in the presence of intact (or increased) raft building”
  5. In the last 14 years, nobody ever had a chance to read or comment on any of the contents of my books. For this reason, some of the contents included within some of the sections may not be perfectly accurate.
    It does not matter if some parts of the sections in each book are not correct; the most important piece of information is related to the basic knowledge of the main theory. I advise my colleagues to always think about the basic theory and its relation to diseases they are dealing with.
  6. Apart from my knowledge in most aspects of physiology and pathology (including clinical/molecular knowledge about diseases in various organs in both children and adults, and basic knowledge about membrane lipid rafts, exocytosis, cytokinesis, apoptosis, shedding of microvesicles, unconventional secretion, and the function of primary immotile cilia), I did not do any molecular testing to prove or disprove my theory. In fact, the evidence and proof are available within thousands of papers, referenced at the end of each book, done by doctors, researchers, and scientists in the last 50 years; you just have to look at them in a different way and at the nano-level.
  7. The theory states that the disease mechanism is the same regardless of age, organ, or cause. For this reason, the reader should have some information about various diseases in children and adults in order to understand the basic mechanism of any disease. Some of these disorders include PFIC1, Cystic fibrosis (CF), ADPKD, PBC, Tangier disease (TD), and Scott syndrome (SC). I wrote one full book for each of these disorders. Two books are written for some of these disorders (e.g. Cystic fibrosis and Tangier disease).
  8. Various colleagues may adopt various attitudes toward the contents of each book; some might be passive about the whole subject; some might look for or discover mistakes and waste their time by exposing wrong statements, sections, or ideas; and some might be positive by trying to understand, follow possible proofs, and apply what looks logical and reasonable.
  9. Despite the highly speculative nature of the whole subject, these books and the theory behind are very powerful tools that will push medicine years ahead regarding disease mechanism and therapeutic options. I hope that wise colleagues take the chance and explore/use the treasure of knowledge buried within various sections in different books.
  10. My objective is to change the history of medicine. I hope that I can achieve this while I am alive.