Volume 25. Inflammatory Membrane Microdomain Phenotypes

Description

A unified mechanism for any human disease is proposed in this book series based on abnormal membrane microdomain phenotypes. Diseases are classified into inflammatory and non-inflammatory phenotypes. This book describes the mechanism of chronic inflammation, proliferation, and aging based on modulations of membrane microdomains orchestrated by ABC transporters, P4-ATPases, and scramblases. Primary loss or secondary inactivation of ABCA1 is discussed as a prototype example of chronic inflammation induced by impaired raft disruption.